Understanding the JAK-STAT Pathway
Program Information
This program will teach the basics of intra-cellular signalling including the JAK-STAT pathway. The efficacy and safety of agents that block this pathway in patients with rheumatoid arthritis will be explained.
Ce programme est disponible en français : Comprendre la voie JAK-STAT
- Credits: 8 RheumTalks Credits
- Recommended Audience: Rheumatologists, Rheumatology Trainees, and Advanced Practice Therapists working in Rheumatology
- Estimated Time: 1-2 hours
Modules
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Cellular Communication
Module
This module will explore the reasons cells talk with each other and the methods they use to communicate with each other.
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Receptor Signalling
Module
In this module we’ll learn a little more about receptor signaling and the concept of signal transduction.
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Protein Kinases
Module
In this module you’ll learn what a protein kinase does and also about one specific type of protein kinase called a tyrosine kinase.
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The JAK-STAT Pathway
Module
In this module we’ll explore the JAK-STAT pathway in more detail.
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Inhibiting the JAK-STAT Pathway
Module
In this module we’ll explore the history of the science of JAK inhibition.
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Tofacitinib Efficacy
Module
In this module we’ll explore the efficacy of JAK-1,3 inhibition with Tofacitinib in rheumatoid arthritis.
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Tofacitinib Safety
Module
In this module we’ll start by exploring the serious adverse events associated with tofacitinib. We’ll then discuss other common side effects of tofacitinib.
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Tofacitinib Practical Questions
Module
In this final module we’ll discuss some very practical issues about tofacitinib including dosing, onset of action, and monitoring.